Cyclin E1(Phospho-Thr62) Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the highly conserved cyclin family| whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2| whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors| which results in chromosome instability| and thus may contribute to tumorigenesis. This protein was found to associate with| and be involved in| the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus)| which participates in

The Cyclin E1(Phospho-Thr62) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Cyclin E1 protein phosphorylated at Thr62. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Cyclin E1 is a critical regulator of the cell cycle, playing a crucial role in the transition from G1 to S phase. Phosphorylation of Cyclin E1 at Thr62 has been shown to modulate its stability and activity, making it an important target for studying cell cycle progression and proliferation.

The Cyclin E1(Phospho-Thr62) Rabbit Polyclonal Antibody exhibits exceptional specificity, binding only to Cyclin E1 protein phosphorylated at Thr62, while showing minimal cross-reactivity with non-phosphorylated Cyclin E1 or other related proteins. This high specificity ensures accurate and reliable results, minimizing false positives and false negatives.

Furthermore, this antibody demonstrates excellent sensitivity, allowing for the detection of low levels of phosphorylated Cyclin E1 protein. This sensitivity is crucial for studying subtle changes in Cyclin E1 phosphorylation levels, which can have significant implications for cell cycle regulation and disease progression.

The Cyclin E1(Phospho-Thr62) Rabbit Polyclonal Antibody has been extensively validated in various experimental conditions and has consistently shown outstanding performance. It is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation, and ensuring convenience and efficiency in laboratory workflows.

In summary, the Cyclin E1(Phospho-Thr62) Rabbit Polyclonal Antibody is a reliable and highly specific tool for the detection and quantification of phosphorylated Cyclin E1 protein. Its exceptional sensitivity and specificity make it an invaluable asset for researchers studying cell cycle regulation, proliferation, and related diseases.