IGF-IR(Phospho Tyr1346) Polyclonal Antibody

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

The IGF-IR(Phospho Tyr1346) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of insulin-like growth factor 1 receptor (IGF-IR) phosphorylated at tyrosine 1346. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The IGF-IR is a transmembrane receptor that plays a crucial role in mediating the biological effects of insulin-like growth factors (IGFs). Phosphorylation of tyrosine residues in the IGF-IR is a key event in the activation of downstream signaling pathways, leading to cellular proliferation, survival, and differentiation. The phosphorylation of tyrosine 1346 in particular has been implicated in various physiological and pathological processes, making it an important target for research and diagnostic applications.

This polyclonal antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results. The antibody is supplied as a purified and lyophilized form, allowing for long-term storage and convenient reconstitution.

The IGF-IR(Phospho Tyr1346) Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in studying the IGF-IR signaling pathway and its implications in various diseases, including cancer, diabetes, and neurodegenerative disorders. Its high specificity and sensitivity make it an ideal choice for applications such as protein expression analysis, biomarker discovery, and drug development.

In summary, the IGF-IR(Phospho Tyr1346) Polyclonal Antibody offers a reliable and efficient solution for the detection and quantification of phosphorylated IGF-IR at tyrosine 1346. With its advanced technology and rigorous validation, this antibody is a valuable asset for researchers and clinicians seeking to unravel the complexities of IGF-IR signaling and its role in disease progression.