IGF-IR(Phospho Tyr1161) Polyclonal Antibody

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

The IGF-IR(Phospho Tyr1161) Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of insulin-like growth factor 1 receptor (IGF-IR) phosphorylated at tyrosine 1161. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the phosphorylated form of IGF-IR.

The IGF-IR is a transmembrane receptor that plays a crucial role in mediating the cellular responses to insulin-like growth factors (IGFs). Phosphorylation of tyrosine residues in the IGF-IR is a key event in the activation of downstream signaling pathways, leading to cellular proliferation, survival, and differentiation. The phosphorylation of tyrosine 1161 in particular has been implicated in various physiological and pathological processes, including cancer development and progression.

This polyclonal antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated IGF-IR and other related proteins, ensuring accurate and reliable detection of the phosphorylated form of IGF-IR.

The IGF-IR(Phospho Tyr1161) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use in various immunological applications. It is recommended for use in research studies aimed at investigating the role of IGF-IR phosphorylation in cellular signaling pathways, as well as in diagnostic applications for the detection of IGF-IR phosphorylation in clinical samples.

With its exceptional specificity, sensitivity, and reliability, the IGF-IR(Phospho Tyr1161) Polyclonal Antibody is an indispensable tool for researchers and clinicians working in the fields of cancer biology, cell signaling, and molecular medicine.