IGF-IIR(Phospho Ser2409) Polyclonal Antibody

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions| including in the intracellular trafficking of lysosomal enzymes| the activation of transforming growth factor beta| and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however| imprinting of the human gene may be polymorphic| as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).

The IGF-IIR(Phospho Ser2409) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the insulin-like growth factor II receptor (IGF-IIR) protein phosphorylated at serine 2409. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

The IGF-IIR is a transmembrane receptor that plays a crucial role in mediating the biological effects of insulin-like growth factor II (IGF-II). Phosphorylation of the IGF-IIR at serine 2409 has been implicated in various cellular processes, including cell growth, differentiation, and survival. Therefore, the detection and quantification of this phosphorylation event are of great importance in understanding the molecular mechanisms underlying these processes.

This polyclonal antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results.

The IGF-IIR(Phospho Ser2409) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use in various applications, including research studies, drug development, and diagnostic assays. It is provided in a convenient size and concentration, allowing for easy handling and storage.

In summary, the IGF-IIR(Phospho Ser2409) Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of the phosphorylated form of the IGF-IIR protein at serine 2409. Its advanced technology, rigorous validation, and convenient formulation make it an ideal choice for researchers and scientists working in the field of cellular signaling and growth regulation.