Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins| extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin| a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities| so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Introducing the Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody, a highly specific and sensitive tool for the detection of Collagen XVIII alpha 1 protein in various biological samples. This antibody has been raised in rabbits using a synthetic peptide corresponding to the cleaved His1572 region of Collagen XVIII alpha 1 protein as an immunogen. The antibody has been purified using protein A affinity chromatography and characterized for its specificity and sensitivity by various immunoassays.

The Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody is suitable for use in various applications such as Western blotting, immunohistochemistry, and ELISA. It recognizes the cleaved His1572 region of Collagen XVIII alpha 1 protein with high specificity and sensitivity, making it an ideal tool for the detection and quantification of Collagen XVIII alpha 1 protein in biological samples.

This antibody is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different applications. The Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody is a reliable and high-quality product that is backed by our commitment to quality and customer satisfaction.