TRAP220(Phospho Thr1457) Polyclonal Antibody

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex| which| along with TFIID| is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.

The TRAP220(Phospho Thr1457) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Thr1457 residues on the TRAP220 protein. This antibody has been meticulously developed and rigorously validated to ensure optimal performance and reliability in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The TRAP220 protein, also known as thyroid hormone receptor-associated protein 220, plays a crucial role in transcriptional regulation and is involved in diverse cellular processes. Phosphorylation of Thr1457 on TRAP220 has been implicated in the modulation of its activity and function, making it an important target for investigation in various biological and pathological contexts.

This polyclonal antibody has been generated using high-quality immunogens and state-of-the-art techniques, resulting in a highly specific and sensitive reagent. It exhibits minimal cross-reactivity with non-phosphorylated forms of TRAP220, ensuring accurate and reliable detection of phosphorylated Thr1457 residues. The antibody has been extensively validated using positive and negative controls, demonstrating its specificity and reproducibility.

The TRAP220(Phospho Thr1457) Polyclonal Antibody offers exceptional performance characteristics, including high sensitivity, low background, and excellent signal-to-noise ratio. It enables precise and quantitative analysis of phosphorylated Thr1457 residues on TRAP220, facilitating a deeper understanding of the molecular mechanisms underlying cellular processes and disease pathogenesis.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and format, ensuring ease of handling and storage. The product is accompanied by comprehensive technical documentation, including recommended protocols and troubleshooting tips, to support successful experimental outcomes.

In summary, the TRAP220(Phospho Thr1457) Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of phosphorylated Thr1457 residues on the TRAP220 protein. Its exceptional performance characteristics, combined with rigorous validation and comprehensive technical support, make it an invaluable asset for researchers in the fields of molecular biology, biochemistry, and cellular signaling.