Stat3(Phospho Tyr705) Polyclonal Antibody

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs| EGF| IL5| IL6| HGF| LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli| and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper

The Stat3(Phospho Tyr705) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Stat3 at Tyr705 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The Stat3 protein plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. Phosphorylation of Stat3 at Tyr705 residue is a key event in its activation, leading to the transcriptional regulation of genes involved in cell proliferation and immune response.

This polyclonal antibody is rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Stat3 in various sample types.

The Stat3(Phospho Tyr705) Polyclonal Antibody is supplied as a liquid formulation, ready to use for laboratory research purposes. It is provided in a convenient size and quantity, ensuring cost-effectiveness and minimizing wastage.

With its exceptional performance and reliability, the Stat3(Phospho Tyr705) Polyclonal Antibody is an indispensable tool for researchers studying the role of Stat3 phosphorylation in cellular signaling pathways, cancer biology, and immunology.