Stat3 (Acetyl Lys87) Polyclonal Antibody

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs| EGF| IL5| IL6| HGF| LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli| and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper

The Stat3 (Acetyl Lys87) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Stat3 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated lysine 87 of human Stat3 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Stat3 protein is a transcription factor that plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. The acetylation of lysine 87 in Stat3 has been shown to enhance its transcriptional activity and promote tumor growth and metastasis. Therefore, the Stat3 (Acetyl Lys87) Polyclonal Antibody is an essential tool for researchers studying the role of Stat3 in cancer and other diseases.

This antibody has been validated for use in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It has been shown to specifically recognize acetylated Stat3 protein in human, mouse, and rat samples. The antibody has a high affinity and sensitivity, allowing for the detection of low levels of acetylated Stat3 protein in complex biological samples.

In summary, the Stat3 (Acetyl Lys87) Polyclonal Antibody is a reliable and specific tool for the detection of acetylated Stat3 protein in various biological samples. Its high sensitivity and specificity make it an essential reagent for researchers studying the role of Stat3 in cancer and other diseases.