Stat2(Phospho Tyr690) Polyclonal Antibody

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN)| this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G)| in which this protein acts as a transactivator| but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein| which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

The Stat2(Phospho Tyr690) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated tyrosine 690 on the Stat2 protein. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target epitope.

The Stat2 protein plays a crucial role in the signal transduction pathway mediated by the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. Phosphorylation of tyrosine 690 on Stat2 is a key event in the activation of this pathway, leading to the transcriptional regulation of various genes involved in immune response, cell growth, and differentiation.

The Stat2(Phospho Tyr690) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated tyrosine 690 on Stat2 in various sample types, including cell lysates and tissue extracts.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. The Stat2(Phospho Tyr690) Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.

In summary, the Stat2(Phospho Tyr690) Polyclonal Antibody is a valuable tool for researchers studying the JAK-STAT signaling pathway and its role in various biological processes. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory involved in signal transduction research.