SMC1(Phospho Ser966) Polyclonal Antibody

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins| SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis| although those complexes at the kinetochore remain. Therefore| the encoded protein is thought to be an important part of functional kinetochores. In addition| this protein interacts with BRCA1 and is phosphorylated by ATM| indicating a potential role for this protein in DNA repair. This gene| which belongs to the SMC gene family| is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Altern

The SMC1(Phospho Ser966) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of SMC1 protein phosphorylated at Ser966. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

SMC1, also known as Structural Maintenance of Chromosomes 1, plays a crucial role in the maintenance of genome stability and proper chromosome segregation during cell division. Phosphorylation of SMC1 at Ser966 has been implicated in various cellular processes, including DNA repair, cell cycle regulation, and chromatin remodeling.

The SMC1(Phospho Ser966) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated SMC1 at Ser966 in various biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage. The SMC1(Phospho Ser966) Polyclonal Antibody is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

In summary, the SMC1(Phospho Ser966) Polyclonal Antibody is a valuable tool for researchers and clinicians studying the role of SMC1 phosphorylation in cellular processes. Its high specificity, sensitivity, and versatility make it an essential component of any study involving SMC1 protein analysis.