Smad2/3(Phospho Thr8) Polyclonal Antibody

The protein encoded by this gene belongs to the SMAD| a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta| and thus regulates multiple cellular processes| such as cell proliferation| apoptosis| and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal| this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation

The Smad2/3(Phospho Thr8) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Smad2 and Smad3 proteins phosphorylated at threonine 8 residue. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The Smad2/3(Phospho Thr8) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of Smad2 and Smad3, making it an ideal choice for researchers studying the TGF-β signaling pathway. It recognizes the phosphorylated threonine 8 residue with high affinity, enabling accurate and precise quantification of the phosphorylated Smad2 and Smad3 proteins.

This antibody is validated for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been extensively tested and proven to provide reliable and reproducible results across a wide range of experimental conditions. The high sensitivity of this antibody allows for the detection of low levels of phosphorylated Smad2 and Smad3 proteins, making it suitable for both qualitative and quantitative analysis.

The Smad2/3(Phospho Thr8) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, ensuring ease of use and storage. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also available in different sizes to accommodate various experimental requirements.

In summary, the Smad2/3(Phospho Thr8) Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of phosphorylated Smad2 and Smad3 proteins. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers in the field of TGF-β signaling pathway studies.