Rb(Phospho Ser807) Polyclonal Antibody

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active| hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB)| bladder cancer| and osteogenic sarcoma.

The Rb(Phospho Ser807) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Ser807 residues on the retinoblastoma protein (Rb). This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target epitope.

The retinoblastoma protein plays a crucial role in cell cycle regulation and tumor suppression. Phosphorylation of specific serine residues, such as Ser807, is known to modulate the activity of Rb and its interaction with various cellular proteins. Therefore, the ability to accurately detect and quantify phosphorylated Ser807 residues is of utmost importance in understanding the molecular mechanisms underlying cell cycle control and cancer development.

The Rb(Phospho Ser807) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling researchers to confidently investigate the phosphorylation status of Ser807 in various biological samples. This antibody has been extensively validated using a range of experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence, ensuring reliable and reproducible results.

Furthermore, the Rb(Phospho Ser807) Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy integration into existing laboratory protocols. It is compatible with a wide range of applications, including basic research, drug discovery, and clinical diagnostics.

In summary, the Rb(Phospho Ser807) Polyclonal Antibody is a highly reliable and versatile tool for the detection and quantification of phosphorylated Ser807 residues on the retinoblastoma protein. Its exceptional sensitivity, specificity, and ease of use make it an invaluable asset for researchers and clinicians alike in their pursuit of understanding and combating cancer.