Rb(Phospho Ser780) Polyclonal Antibody

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active| hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB)| bladder cancer| and osteogenic sarcoma.

The Rb(Phospho Ser780) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Ser780 residues on the retinoblastoma protein (Rb). This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target epitope.

The retinoblastoma protein plays a crucial role in cell cycle regulation and tumor suppression. Phosphorylation of Ser780 residue on Rb has been implicated in various cellular processes, including cell proliferation, differentiation, and apoptosis. Therefore, the ability to accurately measure the phosphorylation status of Ser780 is of great importance in understanding the molecular mechanisms underlying these processes.

The Rb(Phospho Ser780) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling precise detection and quantification of phosphorylated Ser780 residues on Rb. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is supplied as a liquid formulation, allowing for easy handling and convenient storage. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps. The Rb(Phospho Ser780) Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

With its superior performance characteristics and broad applicability, the Rb(Phospho Ser780) Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of Rb phosphorylation in cellular processes and disease development. Its reliable and reproducible results make it an ideal choice for both basic research and clinical applications.

Order your Rb(Phospho Ser780) Polyclonal Antibody today and unlock new insights into the intricate mechanisms governing cell cycle regulation and tumor suppression.