Raf-1(Phospho Ser296) Polyclonal Antibody

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K)| which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated| the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2| which in turn phosphorylate to activate the serine/threonine specific protein kinases| ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle| apoptosis| cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

The Raf-1(Phospho Ser296) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Raf-1 protein phosphorylated at Serine 296. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Raf-1 is a crucial protein kinase involved in the regulation of cell growth, differentiation, and survival. Phosphorylation of Raf-1 at Serine 296 plays a critical role in its activation and subsequent downstream signaling cascades. Therefore, the detection and analysis of phosphorylated Raf-1 at Serine 296 are of utmost importance in understanding the intricate mechanisms underlying cellular processes.

The Raf-1(Phospho Ser296) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It has been rigorously validated for its specificity and sensitivity, ensuring reliable and reproducible results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without compromising its quality. The Raf-1(Phospho Ser296) Polyclonal Antibody is manufactured under strict quality control standards, guaranteeing consistent and reliable performance.

In summary, the Raf-1(Phospho Ser296) Polyclonal Antibody is an indispensable tool for researchers and scientists studying Raf-1 signaling pathways. Its high specificity, sensitivity, and reliability make it an ideal choice for accurate detection and quantification of phosphorylated Raf-1 at Serine 296, facilitating a deeper understanding of cellular processes and potential therapeutic targets.