p53(Phospho Ser46) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation| DNA binding| and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes| thereby inducing cell cycle arrest| apoptosis| senescence| DNA repair| or changes in metabolism. Mutations in this gene are associated with a variety of human cancers| including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546| 20937277).

The p53(Phospho Ser46) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 46 residue on the p53 protein. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p53 protein is a crucial regulator of cell cycle progression and plays a pivotal role in maintaining genomic stability. Phosphorylation of serine 46 residue on p53 has been implicated in various cellular processes, including apoptosis, DNA repair, and tumor suppression. Therefore, the ability to accurately measure the phosphorylation status of p53 at serine 46 is of utmost importance in understanding its functional significance and its involvement in disease progression.

Our p53(Phospho Ser46) Polyclonal Antibody exhibits exceptional specificity and sensitivity, enabling precise detection and quantification of phosphorylated serine 46 residue on p53. It has been extensively validated using various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring its reliability and reproducibility across different applications.

Furthermore, this antibody demonstrates excellent performance in a wide range of sample types, including cell lysates, tissue extracts, and biological fluids. Its versatility and robustness make it an ideal choice for researchers and clinicians working in the fields of cancer biology, molecular biology, and drug discovery.

In summary, the p53(Phospho Ser46) Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of phosphorylated serine 46 residue on the p53 protein. Its exceptional performance, versatility, and rigorous quality control measures make it an invaluable asset for researchers and clinicians alike.