p53(Phospho Ser378) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation| DNA binding| and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes| thereby inducing cell cycle arrest| apoptosis| senescence| DNA repair| or changes in metabolism. Mutations in this gene are associated with a variety of human cancers| including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546| 20937277).

The p53(Phospho Ser378) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 378 residue on the p53 protein. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target epitope.

The p53 protein is a crucial tumor suppressor that plays a pivotal role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of serine 378 on p53 has been implicated in various cellular processes, including DNA damage response and cell cycle arrest. Therefore, the ability to accurately measure the phosphorylation status of this residue is of utmost importance in understanding the functional dynamics of p53 and its involvement in disease progression.

This polyclonal antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated p53 and other related proteins, ensuring reliable and accurate results.

The p53(Phospho Ser378) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use in various applications, including but not limited to immunohistochemistry, flow cytometry, and ELISA. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

With its exceptional performance characteristics and broad applicability, the p53(Phospho Ser378) Polyclonal Antibody is an indispensable tool for researchers and scientists studying the intricate mechanisms of p53 signaling pathways and its implications in cancer biology and therapeutic interventions.