NFκB-p65(Phospho Thr505) Polyclonal Antibody

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor| NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL| RELA| or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene| RELA. Four transcript variants encoding different isoforms have been found for this gene.

The NFκB-p65(Phospho Thr505) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated NFκB-p65 at Thr505 residue. This antibody is produced using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the phosphorylated form of NFκB-p65.

The NFκB-p65 transcription factor plays a crucial role in the regulation of various cellular processes, including inflammation, immune response, and cell survival. Phosphorylation of NFκB-p65 at Thr505 has been implicated in the modulation of its transcriptional activity and downstream signaling pathways. Therefore, the ability to accurately measure the phosphorylation status of NFκB-p65 at Thr505 is of great importance in understanding its functional role in cellular processes.

The NFκB-p65(Phospho Thr505) Polyclonal Antibody offers outstanding performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated NFκB-p65 and other related proteins, ensuring reliable and specific detection of the phosphorylated form.

With its high sensitivity and specificity, the NFκB-p65(Phospho Thr505) Polyclonal Antibody is an invaluable tool for researchers studying NFκB-p65 signaling pathways and its involvement in various diseases, such as cancer, autoimmune disorders, and inflammatory conditions. Its superior performance and reliability make it an essential component of any laboratory focused on understanding the intricate mechanisms of NFκB-p65 regulation.