NFκB-p65(Phospho Ser468) Polyclonal Antibody

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor| NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL| RELA| or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene| RELA. Four transcript variants encoding different isoforms have been found for this gene.

The NFκB-p65(Phospho Ser468) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of NFκB-p65 protein phosphorylated at Ser468. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

NFκB-p65 is a key transcription factor involved in the regulation of various cellular processes, including inflammation, immune response, and cell survival. Phosphorylation of NFκB-p65 at Ser468 has been shown to play a critical role in the activation and nuclear translocation of this protein, leading to the modulation of downstream gene expression.

The NFκB-p65(Phospho Ser468) Polyclonal Antibody exhibits excellent specificity towards the phosphorylated form of NFκB-p65, with minimal cross-reactivity to non-phosphorylated NFκB-p65 or other related proteins. This high specificity ensures accurate and reliable results in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is supplied as a liquid formulation, ready for immediate use. It has been validated for use in multiple species, including human, mouse, and rat, making it suitable for a wide range of research applications. Each batch of the NFκB-p65(Phospho Ser468) Polyclonal Antibody undergoes rigorous quality control testing to ensure consistent performance and lot-to-lot reproducibility.

In summary, the NFκB-p65(Phospho Ser468) Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of phosphorylated NFκB-p65 protein. Its exceptional performance and versatility make it an essential reagent for researchers studying NFκB signaling pathways and related cellular processes.