NFκB-p65(Phospho Ser276) Polyclonal Antibody

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor| NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL| RELA| or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene| RELA. Four transcript variants encoding different isoforms have been found for this gene.

The NFκB-p65(Phospho Ser276) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of NFκB-p65 protein phosphorylated at Ser276. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

NFκB-p65 is a key transcription factor involved in the regulation of various cellular processes, including inflammation, immune response, and cell survival. Phosphorylation of NFκB-p65 at Ser276 has been shown to play a critical role in the activation of NFκB signaling pathway and subsequent gene expression.

The NFκB-p65(Phospho Ser276) Polyclonal Antibody exhibits excellent specificity towards the phosphorylated form of NFκB-p65, enabling accurate detection and quantification of this important protein modification. It has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is supplied as a liquid formulation, ready to use for various applications. It is recommended to store the antibody at -20°C for long-term storage and avoid repeated freeze-thaw cycles to maintain its stability and activity.

With its high specificity, sensitivity, and reliability, the NFκB-p65(Phospho Ser276) Polyclonal Antibody is an essential tool for researchers studying NFκB signaling pathway and its role in various physiological and pathological processes.