NFκB-p105(Phospho Ser907) Polyclonal Antibody

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines| oxidant-free radicals| ultraviolet irradiation| and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof

The NFκB-p105(Phospho Ser907) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of NFκB-p105 protein phosphorylated at Ser907. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The NFκB-p105 protein plays a crucial role in the regulation of various cellular processes, including immune response, inflammation, and cell survival. Phosphorylation of NFκB-p105 at Ser907 has been shown to modulate its activity and function, making it an important target for research in the field of signal transduction and cellular signaling pathways.

This polyclonal antibody is generated by immunizing animals with a synthetic phospho-peptide corresponding to the phosphorylated Ser907 region of NFκB-p105. It has been extensively validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence.

The NFκB-p105(Phospho Ser907) Polyclonal Antibody exhibits excellent performance in detecting phosphorylated NFκB-p105 protein in a wide range of sample types, including cell lysates, tissue extracts, and cultured cells. It provides reliable and reproducible results, enabling accurate quantification and analysis of NFκB-p105 phosphorylation levels.

With its high specificity and sensitivity, this antibody is an invaluable tool for researchers studying NFκB-p105 signaling pathways and its involvement in various physiological and pathological processes. It offers a comprehensive solution for investigating the role of NFκB-p105 phosphorylation in cellular responses and disease development.

In summary, the NFκB-p105(Phospho Ser907) Polyclonal Antibody is a top-quality research reagent that enables precise and reliable detection of phosphorylated NFκB-p105 protein. Its exceptional performance and versatility make it an essential tool for scientists and researchers in the field of molecular biology, immunology, and signal transduction.