NFκB-p100(Phospho Ser865) Polyclonal Antibody

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas| some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.

The NFκB-p100(Phospho Ser865) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of NFκB-p100 protein phosphorylated at Ser865. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

NFκB-p100 is a key regulator of various cellular processes, including inflammation, immune response, and cell survival. Phosphorylation of NFκB-p100 at Ser865 plays a crucial role in modulating its activity and downstream signaling pathways. Therefore, the ability to accurately measure the phosphorylation status of NFκB-p100 at Ser865 is essential for understanding its functional role in cellular processes.

The NFκB-p100(Phospho Ser865) Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated NFκB-p100 and other related proteins, ensuring reliable and accurate results.

This antibody is supplied as a liquid formulation, ready for immediate use in various applications, including protein expression analysis, cellular localization studies, and functional assays. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

With its exceptional performance and reliability, the NFκB-p100(Phospho Ser865) Polyclonal Antibody is an indispensable tool for researchers and scientists studying NFκB signaling pathways and its involvement in various physiological and pathological conditions.