Neu(Phospho Tyr1221/Y1222) Polyclonal Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported| with the most common allele| Ile654/Ile655| shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors. Alternative splicing results in several additional transcript variants| some encoding d

The Neu(Phospho Tyr1221/Y1222) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of Neu protein phosphorylated at Tyr1221 and Tyr1222 residues. This antibody has been rigorously validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The Neu protein, also known as ErbB2 or HER2, is a member of the epidermal growth factor receptor (EGFR) family and plays a crucial role in cell growth, differentiation, and survival. Phosphorylation of Neu at Tyr1221 and Tyr1222 residues is known to regulate its signaling pathway and is associated with various diseases, including cancer.

The Neu(Phospho Tyr1221/Y1222) Polyclonal Antibody has been developed using high-quality immunogens and advanced immunization techniques. It exhibits excellent specificity and sensitivity, ensuring accurate and reliable results. This antibody recognizes the phosphorylated form of Neu protein specifically at Tyr1221 and Tyr1222 residues, while showing minimal cross-reactivity with non-phosphorylated Neu or other related proteins.

With its superior performance, the Neu(Phospho Tyr1221/Y1222) Polyclonal Antibody is an indispensable tool for researchers studying the role of Neu phosphorylation in various biological processes and diseases. Its versatility allows for a wide range of applications, enabling detailed investigations into the molecular mechanisms underlying Neu signaling.

Order the Neu(Phospho Tyr1221/Y1222) Polyclonal Antibody today and unlock new insights into the complex biology of Neu protein phosphorylation. Trust in its exceptional quality and performance to advance your research and contribute to the understanding and treatment of diseases associated with aberrant Neu signaling.