MYPT1(Phospho Thr853) Polyclonal Antibody

Myosin phosphatase target subunit 1| which is also called the myosin-binding subunit of myosin phosphatase| is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation| which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound| active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase| which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase)| which is activated by GTP. RhoA| phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosph

The MYPT1(Phospho Thr853) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MYPT1 protein phosphorylated at threonine 853 residue. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The MYPT1 protein plays a crucial role in the regulation of smooth muscle contraction and is involved in various physiological processes. Phosphorylation of MYPT1 at threonine 853 is known to modulate its activity and influence smooth muscle contraction.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental conditions. It exhibits minimal cross-reactivity with non-phosphorylated MYPT1 and other related proteins, ensuring accurate and reliable results.

The MYPT1(Phospho Thr853) Polyclonal Antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is compatible with various sample types, including cell lysates, tissue extracts, and purified proteins.

With its high specificity, sensitivity, and versatility, the MYPT1(Phospho Thr853) Polyclonal Antibody is an essential tool for researchers studying smooth muscle contraction, signal transduction pathways, and related cellular processes. It provides valuable insights into the phosphorylation status of MYPT1 and its functional implications, facilitating a deeper understanding of cellular mechanisms and potential therapeutic targets.