MSK1(Phospho Thr581) Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|enzyme regulation:Appears to be activated by multiple phosphorylations on threonine and serine residues. ERK1/2 and MAPK14/p38-alpha may play a role in this process.|Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics| stress stimuli and epidemal growth-factor (EGF)| which results in the transcriptional activation of several immediate early genes| including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).|miscellaneous:Enzyme activity requires the presence of both kinase domains.|PTM:Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain| and their phosphorylation is essential for the Catalytic activity of the N-terminal kinase domain.|Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.|Contains 1 AGC-kinase C-terminal domain.|Contains 2 protein kinase domains.|subcellular location:Predominantly nuclear. Partially cytoplasmic.|subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.|tissue specificity:Widely expressed with high levels in heart| brain and placenta. Less abundant in lung| kidney and liver.|

The MSK1(Phospho Thr581) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MSK1 protein phosphorylated at threonine 581. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

MSK1, also known as Mitogen- and Stress-Activated Protein Kinase 1, is a serine/threonine kinase that plays a crucial role in various cellular processes, including gene expression, cell proliferation, and cell survival. Phosphorylation of MSK1 at threonine 581 is a key regulatory event that modulates its activity and function.

The MSK1(Phospho Thr581) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of MSK1 at threonine 581, enabling accurate and precise detection in various experimental settings. This antibody has been extensively validated and tested in multiple applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its high sensitivity and specificity, the MSK1(Phospho Thr581) Polyclonal Antibody is an invaluable tool for researchers studying the role of MSK1 phosphorylation in cellular signaling pathways and disease mechanisms. Its reliable performance and reproducibility make it an ideal choice for both basic research and clinical applications.

Order the MSK1(Phospho Thr581) Polyclonal Antibody today and unlock new insights into the intricate regulatory mechanisms of MSK1 and its implications in various biological processes.