MDM2(Phospho Ser166) Polyclonal Antibody

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins| such as p53| for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants| many of which may be expressed only in tumor cells.

The MDM2(Phospho Ser166) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MDM2 protein phosphorylated at Ser166. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

MDM2 is a crucial regulator of the tumor suppressor protein p53, playing a pivotal role in cell cycle control, apoptosis, and DNA repair. Phosphorylation of MDM2 at Ser166 has been shown to modulate its activity, leading to altered p53 signaling and potentially contributing to the development and progression of various cancers.

The MDM2(Phospho Ser166) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated MDM2 in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It has been optimized for use in diverse experimental settings, ensuring consistent and reproducible results. The MDM2(Phospho Ser166) Polyclonal Antibody is suitable for both research and diagnostic applications, providing valuable insights into the molecular mechanisms underlying cancer development and progression.

With its exceptional performance characteristics and broad application range, the MDM2(Phospho Ser166) Polyclonal Antibody is an indispensable tool for researchers and clinicians working in the field of cancer biology and therapeutics.