LAT(Phospho Tyr191) Polyclonal Antibody

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation| this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

The LAT(Phospho Tyr191) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of LAT protein phosphorylated at tyrosine 191. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target antigen.

LAT, also known as Linker for Activation of T cells, plays a crucial role in T cell receptor signaling and activation. Phosphorylation of LAT at tyrosine 191 is a key event in the initiation of downstream signaling cascades, leading to T cell activation and immune response.

The LAT(Phospho Tyr191) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated LAT protein in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The product is stored at -20°C to maintain its stability and activity.

With its exceptional performance and reliability, the LAT(Phospho Tyr191) Polyclonal Antibody is an indispensable tool for researchers studying T cell signaling pathways and investigating the role of LAT phosphorylation in immune response regulation.