Caspase 2 Rabbit Polyclonal Antibody

alternative products:Isoforms differ in the N- and C-termini|Catalytic activity:Strict requirement for an Asp residue at P1| with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.|Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.|PTM:The mature protease can process its own propeptide| but not that of other caspases.|Belongs to the peptidase C14A family.|Contains 1 CARD domain.|subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers| each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.|tissue specificity:Expressed at higher levels in the embryonic lung| liver and kidney than in the heart and brain. In adults| higher level expression is seen in the placenta| lung| kidney| and pancreas than in the heart| brain| liver and skeletal muscle.|

The Caspase 2 Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Caspase 2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Caspase 2 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Caspase 2 Rabbit Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize Caspase 2 protein in human, mouse, and rat tissues and cell lines. The antibody has a high affinity and sensitivity, allowing for the detection of low levels of Caspase 2 protein in samples.

This antibody is an essential tool for researchers studying the role of Caspase 2 in various biological processes, including apoptosis, inflammation, and cancer. It can be used to investigate the expression and activation of Caspase 2 in different tissues and cell types, as well as to study the effects of Caspase 2 inhibitors and activators.

In summary, the Caspase 2 Rabbit Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results in various applications. Its specificity, sensitivity, and versatility make it an ideal choice for researchers studying Caspase 2 protein in different biological contexts.