Ku-80(Phospho Thr714) Polyclonal Antibody

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase| and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events.  This gene functionally complements Chinese hamster xrs-6| a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

The Ku-80(Phospho Thr714) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Ku-80 protein phosphorylated at threonine 714. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The Ku-80 protein plays a crucial role in DNA repair and maintenance of genomic stability. Phosphorylation of Ku-80 at threonine 714 has been implicated in various cellular processes, including DNA damage response and cell cycle regulation. Therefore, the ability to accurately detect and quantify this phosphorylation event is of utmost importance in understanding the underlying mechanisms and potential therapeutic targets.

This polyclonal antibody exhibits exceptional specificity towards the phosphorylated form of Ku-80 at threonine 714, enabling precise and reliable detection in various experimental settings. It has been extensively validated using a range of techniques, including Western blotting, immunoprecipitation, and immunofluorescence, ensuring its suitability for diverse applications.

The Ku-80(Phospho Thr714) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for efficient and cost-effective experimentation. The antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins, facilitating its versatility in different research areas.

In summary, the Ku-80(Phospho Thr714) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of Ku-80 protein phosphorylated at threonine 714. Its exceptional performance, extensive validation, and compatibility with various techniques and sample types make it an invaluable asset for researchers studying DNA repair, genomic stability, and related cellular processes.