IκB-alpha(phospho Ser32/S36) Polyclonal Antibody

This gene encodes a member of the NF-kappa-B inhibitor family| which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

The IκB-alpha (phospho Ser32/S36) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated IκB-alpha at Ser32/S36 residues. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target antigen.

IκB-alpha is a critical regulator of the nuclear factor kappa B (NF-κB) signaling pathway, which plays a pivotal role in various cellular processes, including inflammation, immune response, and cell survival. Phosphorylation of IκB-alpha at Ser32/S36 residues leads to its degradation, allowing NF-κB to translocate into the nucleus and activate gene expression.

This polyclonal antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated IκB-alpha in various sample types.

The IκB-alpha (phospho Ser32/S36) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

With its exceptional performance and reliability, the IκB-alpha (phospho Ser32/S36) Polyclonal Antibody is an indispensable tool for studying the NF-κB signaling pathway and its involvement in various physiological and pathological processes.