IRP-1(Phospho Ser711) Polyclonal Antibody

The protein encoded by this gene is a bifunctional| cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high| this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low| the protein binds to iron-responsive elements (IREs)| which are stem-loop structures found in the 5' UTR of ferritin mRNA| and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE| it results in repression of translation of ferritin mRNA| and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct

The IRP-1(Phospho Ser711) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IRP-1 protein phosphorylated at Ser711 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The IRP-1 protein plays a crucial role in iron metabolism and homeostasis. Phosphorylation of the Ser711 residue has been implicated in the regulation of IRP-1 activity, making it an important target for research in the field of iron metabolism and related disorders.

This antibody has been rigorously validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent performance in detecting and visualizing the phosphorylated form of IRP-1 in various sample types, such as cell lysates, tissue sections, and cultured cells.

With its high sensitivity and specificity, the IRP-1(Phospho Ser711) Polyclonal Antibody offers researchers a reliable tool for studying the role of IRP-1 phosphorylation in iron metabolism and related diseases. Its superior performance and versatility make it an essential component of any laboratory focused on understanding the intricate mechanisms of iron homeostasis.