IGF-IR(Phospho Tyr1165/Y1166) Polyclonal Antibody

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

The IGF-IR(Phospho Tyr1165/Y1166) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of insulin-like growth factor 1 receptor (IGF-IR) phosphorylated at tyrosine residues 1165 and 1166. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the phosphorylated form of IGF-IR.

The insulin-like growth factor 1 receptor plays a crucial role in cellular growth, proliferation, and survival. Phosphorylation of tyrosine residues 1165 and 1166 is a key event in the activation of IGF-IR signaling pathway, leading to downstream signaling cascades that regulate various cellular processes. Therefore, the detection and quantification of phosphorylated IGF-IR at these specific sites is of great importance in understanding the molecular mechanisms underlying cellular growth and development.

The IGF-IR(Phospho Tyr1165/Y1166) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated IGF-IR in various biological samples. It has been extensively validated for use in Western blotting, immunoprecipitation, and immunohistochemistry applications. The antibody demonstrates minimal cross-reactivity with non-phosphorylated IGF-IR and other related proteins, ensuring reliable and specific results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into various experimental protocols. The IGF-IR(Phospho Tyr1165/Y1166) Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of IGF-IR phosphorylation in cellular processes, and it promises to deliver accurate and reproducible results in their investigations.

Note: This product is for research use only and is not intended for diagnostic or therapeutic purposes.