c-Cbl(Phospho-Tyr731) Rabbit Polyclonal Antibody

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia| and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Introducing the c-Cbl(Phospho-Tyr731) Rabbit Polyclonal Antibody, a highly specific and sensitive tool for the detection of c-Cbl protein phosphorylated at tyrosine 731. This antibody has been rigorously tested and validated for use in a variety of applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The c-Cbl protein plays a critical role in regulating cellular signaling pathways, including those involved in growth factor receptor signaling and immune cell activation. Phosphorylation of tyrosine 731 is a key event in the activation of c-Cbl and its downstream signaling functions. The c-Cbl(Phospho-Tyr731) Rabbit Polyclonal Antibody has been specifically designed to recognize and bind to this phosphorylated form of c-Cbl with high affinity and specificity.

This antibody is produced using high-quality rabbit polyclonal antibodies and is purified using a proprietary process to ensure maximum specificity and sensitivity. It has been extensively validated using a range of cell lines and tissues, and has been shown to produce highly specific and reproducible results.

In summary, the c-Cbl(Phospho-Tyr731) Rabbit Polyclonal Antibody is a powerful tool for the detection and analysis of c-Cbl protein phosphorylated at tyrosine 731. Its high specificity and sensitivity make it an ideal choice for a wide range of applications in basic research, drug discovery, and clinical diagnostics.