c-Abl(Phospho-Tyr89) Rabbit Polyclonal Antibody

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes| including cell division| adhesion| differentiation| and response to stress. The activity of the protein is negatively regulated by its SH3 domain| whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation| suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias| most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants| which contain alternative first exons that are spliced to the remaining common exons.

The c-Abl(Phospho-Tyr89) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of c-Abl protein phosphorylated at tyrosine 89. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reproducibility in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The c-Abl protein plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Phosphorylation of c-Abl at tyrosine 89 has been implicated in the regulation of its kinase activity and downstream signaling pathways. Therefore, the ability to specifically detect and quantify this phosphorylation event is of utmost importance in understanding the functional implications of c-Abl in cellular processes and disease states.

The c-Abl(Phospho-Tyr89) Rabbit Polyclonal Antibody exhibits high specificity towards the phosphorylated form of c-Abl at tyrosine 89, with minimal cross-reactivity to non-phosphorylated c-Abl or other proteins. This specificity is crucial for accurate and reliable detection of the phosphorylated form of c-Abl in complex biological samples.

Furthermore, this antibody demonstrates exceptional sensitivity, allowing for the detection of low levels of phosphorylated c-Abl in samples with limited starting material. This attribute is particularly advantageous when working with precious or scarce samples, where maximizing sensitivity is paramount.

The c-Abl(Phospho-Tyr89) Rabbit Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. Its robust formulation ensures long-term stability and consistent performance, enabling reliable and reproducible results across experiments.

In summary, the c-Abl(Phospho-Tyr89) Rabbit Polyclonal Antibody is a valuable tool for researchers studying the role of c-Abl phosphorylation in cellular processes and disease states. Its high specificity, sensitivity, and ease of use make it an ideal choice for a wide range of applications, facilitating accurate and reliable detection and quantification of phosphorylated c-Abl in various experimental settings.