HER2(Phospho-Tyr1139) Polyclonal Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported| with the most common allele| Ile654/Ile655| shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors. Alternative splicing results in several additional transcript variants| some encoding d

The HER2(Phospho-Tyr1139) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of HER2 protein phosphorylated at tyrosine 1139. This antibody is produced using advanced techniques to ensure high affinity and specificity, making it an ideal choice for various applications in research and diagnostics.

The HER2 protein, also known as human epidermal growth factor receptor 2, plays a crucial role in cell growth, differentiation, and survival. Abnormal activation of HER2 signaling has been implicated in various cancers, making it an important target for therapeutic interventions. The phosphorylation of tyrosine 1139 in the HER2 protein is a key event in the activation of downstream signaling pathways.

Our HER2(Phospho-Tyr1139) Polyclonal Antibody has been rigorously validated for its specificity and sensitivity. It exhibits minimal cross-reactivity with other phosphorylated tyrosine residues, ensuring accurate and reliable results. The antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and immunofluorescence.

With its high affinity and sensitivity, the HER2(Phospho-Tyr1139) Polyclonal Antibody enables researchers and clinicians to study the phosphorylation status of HER2 protein in various biological samples. This antibody can aid in understanding the molecular mechanisms underlying HER2 signaling and its role in disease progression. Additionally, it can be used to assess the efficacy of targeted therapies aimed at inhibiting HER2 signaling.

In summary, the HER2(Phospho-Tyr1139) Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of phosphorylated HER2 protein. Its high specificity and sensitivity make it an invaluable asset in research and diagnostic applications related to HER2 signaling and cancer biology.