HDAC5/9(Phospho Ser259/220) Polyclonal Antibody

Histones play a critical role in transcriptional regulation| cell cycle progression| and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins| resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

The HDAC5/9(Phospho Ser259/220) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of HDAC5 and HDAC9 proteins phosphorylated at Ser259 and Ser220 residues, respectively. This antibody is produced using advanced techniques to ensure high affinity and specificity towards the target proteins.

HDAC5 and HDAC9 are members of the histone deacetylase (HDAC) family, which play crucial roles in the regulation of gene expression and chromatin remodeling. Phosphorylation of HDAC5 at Ser259 and HDAC9 at Ser220 has been implicated in various cellular processes, including cell cycle progression, differentiation, and apoptosis.

The HDAC5/9(Phospho Ser259/220) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated HDAC5 and HDAC9 proteins in various biological samples.

This antibody is supplied as a liquid formulation, ready to use for immediate application. It is provided in a convenient size and format, ensuring ease of use and minimizing waste. The HDAC5/9(Phospho Ser259/220) Polyclonal Antibody is an essential tool for researchers studying the role of HDAC5 and HDAC9 phosphorylation in cellular processes and disease mechanisms.

In summary, the HDAC5/9(Phospho Ser259/220) Polyclonal Antibody is a highly reliable and specific reagent for the detection and quantification of phosphorylated HDAC5 and HDAC9 proteins. Its exceptional performance and versatility make it an indispensable tool for researchers in the field of molecular biology and related disciplines.