HDAC5(Phospho Ser498) Polyclonal Antibody

Histones play a critical role in transcriptional regulation| cell cycle progression| and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins| resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

The HDAC5(Phospho Ser498) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of HDAC5 protein phosphorylated at Ser498. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

HDAC5, also known as histone deacetylase 5, is a member of the class IIa histone deacetylase family. It plays a crucial role in the regulation of gene expression by deacetylating histones and non-histone proteins. Phosphorylation of HDAC5 at Ser498 has been implicated in various cellular processes, including cell cycle progression, apoptosis, and cellular differentiation.

The HDAC5(Phospho Ser498) Polyclonal Antibody has been rigorously validated for its specificity and sensitivity. It exhibits minimal cross-reactivity with other HDAC isoforms and non-phosphorylated HDAC5. This antibody has been extensively tested in various applications, including Western blotting, immunohistochemistry, and immunofluorescence, and has consistently demonstrated excellent performance.

With its high affinity and specificity, the HDAC5(Phospho Ser498) Polyclonal Antibody is an invaluable tool for researchers studying the role of HDAC5 phosphorylation in cellular processes and disease mechanisms. Its reliable performance and reproducibility make it an ideal choice for both basic research and clinical applications.

Order the HDAC5(Phospho Ser498) Polyclonal Antibody today and unlock new insights into the intricate regulatory mechanisms governed by HDAC5 phosphorylation.