HDAC1(Phospho Ser421) Polyclonal Antibody

Histone acetylation and deacetylation| catalyzed by multisubunit complexes| play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2| it deacetylates p53 and modulates its effect on cell growth and apoptosis.

The HDAC1(Phospho Ser421) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of HDAC1 protein phosphorylated at Ser421. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

HDAC1, also known as histone deacetylase 1, plays a crucial role in the regulation of gene expression by catalyzing the removal of acetyl groups from histones. Phosphorylation of HDAC1 at Ser421 has been implicated in the modulation of its enzymatic activity and protein-protein interactions, thereby influencing its biological functions.

The HDAC1(Phospho Ser421) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of HDAC1, enabling accurate and precise detection of this post-translational modification. It has been extensively validated using various cell lysates and tissues, ensuring reliable and reproducible results.

This antibody offers several advantages, including high sensitivity, low background, and minimal cross-reactivity with non-phosphorylated HDAC1. It is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage.

In summary, the HDAC1(Phospho Ser421) Polyclonal Antibody is a valuable tool for researchers studying the role of HDAC1 phosphorylation in cellular processes and disease mechanisms. Its exceptional specificity and sensitivity make it an ideal choice for accurate and reliable detection of phosphorylated HDAC1 in various experimental settings.