GRF-1(Phospho Tyr1087) Polyclonal Antibody

The human glucocorticoid receptor DNA binding factor| which associates with the promoter region of the glucocorticoid receptor gene (hGR gene)| is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.

The GRF-1(Phospho Tyr1087) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of GRF-1 protein phosphorylated at Tyr1087. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

GRF-1, also known as growth factor receptor-bound protein 2 (Grb2)-related protein 1, plays a crucial role in various cellular processes, including cell growth, differentiation, and signal transduction. Phosphorylation of GRF-1 at Tyr1087 is known to regulate its function and interaction with other signaling molecules.

The GRF-1(Phospho Tyr1087) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated GRF-1 in complex biological samples.

This antibody is manufactured using high-quality materials and state-of-the-art techniques, ensuring batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.

Researchers and scientists can confidently rely on the GRF-1(Phospho Tyr1087) Polyclonal Antibody to facilitate their investigations into the role and regulation of GRF-1 in various cellular processes. Its exceptional performance and reliability make it an indispensable tool for studying signal transduction pathways and understanding the molecular mechanisms underlying cellular functions.