GR(Phospho Ser226) Polyclonal Antibody

This gene encodes glucocorticoid receptor| which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription| and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm| but upon ligand binding| is transported into the nucleus. It is involved in inflammatory responses| cellular proliferation| and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described| and shown to be functional| displaying diverse cytoplasm-to-nucleus trafficking pat

The GR(Phospho Ser226) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the phosphorylated form of the glucocorticoid receptor (GR) at serine 226. This antibody has been meticulously developed and rigorously validated to ensure optimal performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The phosphorylation of serine 226 on the GR plays a crucial role in regulating its transcriptional activity and cellular response to glucocorticoid hormones. By targeting this specific phosphorylation site, our antibody enables researchers to investigate the intricate signaling pathways and molecular mechanisms involved in GR-mediated cellular processes.

With its exceptional specificity, this polyclonal antibody exhibits minimal cross-reactivity with non-phosphorylated GR and other related proteins, ensuring accurate and reliable results. Its high sensitivity allows for the detection of even low levels of phosphorylated GR, making it an invaluable tool for studying the dynamic regulation of GR phosphorylation in various biological systems.

The GR(Phospho Ser226) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. Its superior performance, combined with its ease of use, makes it an ideal choice for both experienced researchers and those new to the field.

We take pride in the quality and consistency of our products, and the GR(Phospho Ser226) Polyclonal Antibody is no exception. Each batch undergoes rigorous quality control testing to ensure its reliability and reproducibility. Furthermore, our dedicated technical support team is always available to provide assistance and guidance, ensuring a seamless and successful experimental experience.

In summary, the GR(Phospho Ser226) Polyclonal Antibody is a highly specific, sensitive, and reliable tool for investigating the phosphorylation status of the glucocorticoid receptor at serine 226. Its exceptional performance, ease of use, and comprehensive technical support make it an indispensable asset for researchers in the field of molecular biology, cellular signaling, and hormone regulation.