BMAL1(Phospho-Ser42) Rabbit Polyclonal Antibody

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1| PER2| PER3) and Cryptochrome (CRY1| CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility| problems with gluconeogenesis and lipogenesis| and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

The BMAL1(Phospho-Ser42) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of BMAL1 protein phosphorylated at Serine 42. This antibody has been rigorously validated for its specificity and performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The BMAL1 protein plays a crucial role in the regulation of circadian rhythms and is involved in the control of various physiological processes, such as sleep-wake cycles, metabolism, and immune responses. Phosphorylation of BMAL1 at Serine 42 has been shown to modulate its activity and stability, making it an important target for research in the field of circadian biology.

The BMAL1(Phospho-Ser42) Rabbit Polyclonal Antibody has been developed using high-quality rabbit polyclonal antibodies that have been carefully selected and validated for their specificity and sensitivity. The antibody has been affinity-purified using a phospho-peptide corresponding to the phosphorylated Serine 42 region of the BMAL1 protein, ensuring high specificity and minimal cross-reactivity.

This antibody exhibits excellent performance in Western blotting, providing a strong and specific signal at the expected molecular weight of BMAL1 protein phosphorylated at Serine 42. It also demonstrates robust staining in immunohistochemistry and immunofluorescence experiments, allowing for the visualization and localization of phosphorylated BMAL1 protein in various tissues and cell types.

The BMAL1(Phospho-Ser42) Rabbit Polyclonal Antibody is supplied as a liquid formulation in a convenient size of 100 μg. It is recommended for use at a dilution of 1:1000 for Western blotting and 1:200 for immunohistochemistry and immunofluorescence. Each batch of antibody is quality-controlled to ensure consistent performance and reliability.

In summary, the BMAL1(Phospho-Ser42) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of phosphorylated BMAL1 protein at Serine 42. Its excellent performance in various applications makes it an ideal choice for researchers studying circadian biology and related fields.