Bim(Phospho-Ser77) Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF)| as well as by the forkhead transcription factor FKHR-L1| which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

The Bim(Phospho-Ser77) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Bim protein phosphorylated at Serine 77. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring reliable and reproducible results.

Bim, also known as Bcl-2-like protein 11, plays a crucial role in regulating apoptosis, or programmed cell death. Phosphorylation of Bim at Serine 77 has been shown to modulate its activity and stability, making it an important target for research in various biological processes and diseases.

The Bim(Phospho-Ser77) Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready to use for immediate application. It is provided in a convenient size, allowing for multiple experiments and minimizing waste. The Bim(Phospho-Ser77) Rabbit Polyclonal Antibody is suitable for use in both basic research and clinical applications, providing valuable insights into the role of Bim phosphorylation in various cellular processes and diseases.

With its high specificity, sensitivity, and reliability, the Bim(Phospho-Ser77) Rabbit Polyclonal Antibody is an essential tool for researchers and scientists studying apoptosis and related pathways.