BID (p11| Cleaved-Ser100) Rabbit Polyclonal Antibody

Intact BH3 motif is required by BIK| BID| BAK| BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1| isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.|PTM:Phosphorylated upon DNA damage| probably by ATM or ATR.|PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.|subcellular location:A significant proportion of isoform 2 localizes to mitochondria| it may be cleaved constitutively.|subcellular location:Associated with the mitochondrial membrane.|subcellular location:Translocates to mitochondria as an integral membrane protein.|subcellular location:When uncleaved| it is predominantly cytoplasmic.|subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.|tissue specificity:Isoforms 2 and 3 are expressed in spleen| bone marrow| cerebral and cerebellar cortex. Isoform 2 is expressed in spleen| pancreas and placenta (at protein level). Isoform 3 is expressed in lung| pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).|

Introducing the BID (p11| Cleaved-Ser100) Rabbit Polyclonal Antibody, a highly specialized and meticulously crafted product designed to cater to the discerning needs of the scientific community. This antibody, derived from rabbit polyclonal sources, exhibits exceptional specificity and sensitivity in detecting the cleaved form of BID protein at Ser100 residue.

With its cutting-edge technology and rigorous quality control measures, this antibody guarantees reliable and reproducible results, making it an indispensable tool for researchers and scientists engaged in the study of apoptosis and cell death pathways. Its unique ability to specifically recognize the cleaved form of BID protein at Ser100 residue ensures accurate and precise detection, enabling researchers to delve deeper into the intricate mechanisms underlying cellular processes.

The BID (p11| Cleaved-Ser100) Rabbit Polyclonal Antibody boasts an array of remarkable features that set it apart from its counterparts. Its high affinity and selectivity for the target epitope ensure minimal cross-reactivity, thereby enhancing the accuracy and reliability of experimental outcomes. Additionally, its robust performance across a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence, further amplifies its versatility and utility in diverse research settings.

Furthermore, this antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control procedures to ensure optimal performance and consistency. Each batch is meticulously tested to meet the highest standards of quality, guaranteeing reproducibility and reliability in every experiment.

In summary, the BID (p11| Cleaved-Ser100) Rabbit Polyclonal Antibody is an exceptional product that combines cutting-edge technology, unrivaled specificity, and uncompromising quality. Its ability to specifically detect the cleaved form of BID protein at Ser100 residue makes it an invaluable asset for researchers seeking to unravel the complexities of apoptosis and cell death pathways. Trust in this antibody to deliver accurate and reliable results, empowering you to make groundbreaking discoveries in your scientific endeavors.