GluR-2(Phospho Ser880) Polyclonal Antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)| and function as ligand-activated cation channels. These channels are assembled from 4 related subunits| GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain| which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function| and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing| resulting in transcript variants enco

The GluR-2(Phospho Ser880) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of GluR-2 protein phosphorylated at Serine 880. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The GluR-2 protein, a subunit of the AMPA receptor, plays a crucial role in synaptic plasticity and excitatory neurotransmission in the central nervous system. Phosphorylation of GluR-2 at Serine 880 has been implicated in various physiological and pathological processes, including synaptic plasticity, learning, memory, and neurodegenerative diseases.

This polyclonal antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

The GluR-2(Phospho Ser880) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. The antibody is suitable for use in both research and clinical applications, enabling scientists and clinicians to investigate the role of GluR-2 phosphorylation in various biological processes and diseases.

With its exceptional specificity, sensitivity, and versatility, the GluR-2(Phospho Ser880) Polyclonal Antibody is an indispensable tool for researchers and clinicians working in the fields of neuroscience, neurobiology, and neurology. Its reliable performance and reproducibility make it an ideal choice for studying the intricate mechanisms underlying synaptic plasticity and neurological disorders.