FANCD2(Phospho Ser222) Polyclonal Antibody

The Fanconi anemia complementation group (FANC) currently includes FANCA| FANCB| FANCC| FANCD1 (also called BRCA2)| FANCD2| FANCE| FANCF| FANCG| FANCI| FANCJ (also called BRIP1)| FANCL| FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability| hypersensitivity to DNA crosslinking agents| increased chromosomal breakage| and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage| resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repai

The FANCD2(Phospho Ser222) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of FANCD2 protein phosphorylated at Serine 222. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

FANCD2 is a key component of the Fanconi Anemia (FA) pathway, which plays a crucial role in maintaining genomic stability and preventing DNA damage. Phosphorylation of FANCD2 at Serine 222 is known to be an important post-translational modification that regulates its function in DNA repair and cell cycle control.

The FANCD2(Phospho Ser222) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated FANCD2 in various sample types.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The FANCD2(Phospho Ser222) Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.

Researchers and scientists working in the fields of DNA repair, genomics, and cell biology will greatly benefit from the use of this antibody. Its high specificity and sensitivity make it an indispensable tool for studying the role of FANCD2 phosphorylation in DNA repair pathways and its implications in various diseases, including cancer.

In summary, the FANCD2(Phospho Ser222) Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of phosphorylated FANCD2 protein. Its high specificity, sensitivity, and versatility make it an ideal choice for researchers aiming to unravel the intricate mechanisms of DNA repair and genomic stability.