ATR(Phospho-Thr1989) Rabbit Polyclonal Antibody

The protein encoded by this gene belongs the PI3/PI4-kinase family| and is most closely related to ATM| a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3| a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1| checkpoint proteins RAD17| and RAD9| as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported| however| its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

The ATR(Phospho-Thr1989) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of ATR protein phosphorylated at Thr1989. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reproducibility.

ATR, also known as Ataxia Telangiectasia and Rad3-related protein, is a key regulator of the DNA damage response pathway. Phosphorylation of ATR at Thr1989 is crucial for its activation and subsequent initiation of DNA repair processes. Therefore, the ATR(Phospho-Thr1989) Rabbit Polyclonal Antibody serves as an invaluable tool for studying the role of ATR in DNA damage response and related cellular processes.

The ATR(Phospho-Thr1989) Rabbit Polyclonal Antibody exhibits exceptional specificity, as it recognizes only the phosphorylated form of ATR at Thr1989. This specificity ensures minimal cross-reactivity with non-phosphorylated ATR or other proteins, resulting in highly accurate and reliable results.

Furthermore, this antibody demonstrates excellent sensitivity, allowing for the detection of low levels of phosphorylated ATR in various sample types. Its high sensitivity enables researchers to detect subtle changes in ATR phosphorylation levels, facilitating the investigation of ATR-related signaling pathways and their modulation under different experimental conditions.

The ATR(Phospho-Thr1989) Rabbit Polyclonal Antibody is suitable for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its versatility allows researchers to explore ATR phosphorylation in different cellular contexts and investigate its functional implications.

In summary, the ATR(Phospho-Thr1989) Rabbit Polyclonal Antibody is a reliable and powerful tool for studying ATR phosphorylation at Thr1989. Its exceptional specificity, sensitivity, and versatility make it an essential component of any research focused on understanding the DNA damage response pathway and its regulation.