ATF-2(Phospho-Thr69/71) Rabbit Polyclonal Antibody

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE)| an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene

The ATF-2(Phospho-Thr69/71) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of ATF-2 protein phosphorylated at Thr69/71 residues. This antibody has been meticulously developed and rigorously validated to ensure optimal performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The ATF-2 protein plays a crucial role in cellular responses to stress and is involved in the regulation of gene expression. Phosphorylation of ATF-2 at Thr69/71 residues is known to activate its transcriptional activity, leading to the modulation of target gene expression. Therefore, the ability to accurately measure the phosphorylation status of ATF-2 is of utmost importance in understanding its functional role in cellular processes.

Our ATF-2(Phospho-Thr69/71) Rabbit Polyclonal Antibody exhibits exceptional specificity, recognizing only the phosphorylated form of ATF-2 at Thr69/71 residues. This ensures minimal cross-reactivity with non-phosphorylated ATF-2 or other proteins, guaranteeing reliable and accurate results. The antibody has been extensively validated using various cell lysates and tissues, demonstrating its robustness and reproducibility.

With its high sensitivity, this antibody allows for the detection of even low levels of phosphorylated ATF-2, enabling precise quantification and analysis. Its versatility in different applications makes it an invaluable tool for researchers studying ATF-2 signaling pathways and its involvement in various physiological and pathological conditions.

The ATF-2(Phospho-Thr69/71) Rabbit Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It is provided in a liquid form, allowing for direct application without the need for reconstitution or additional preparation steps.

In summary, the ATF-2(Phospho-Thr69/71) Rabbit Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of phosphorylated ATF-2 at Thr69/71 residues. Its exceptional sensitivity, versatility, and ease of use make it an essential component in any research focused on understanding the functional role of ATF-2 in cellular processes.