ErbB-3(Phospho Tyr1289) Polyclonal Antibody

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However| it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers| including prostate| bladder| and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m

The ErbB-3(Phospho Tyr1289) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of ErbB-3 protein phosphorylated at tyrosine 1289. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The ErbB-3 receptor, a member of the epidermal growth factor receptor (EGFR) family, plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival. Phosphorylation of tyrosine 1289 is a key event in the activation of ErbB-3 signaling pathway, leading to downstream signaling cascades and cellular responses.

This polyclonal antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated ErbB-3 protein in complex biological samples.

The ErbB-3(Phospho Tyr1289) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effective and efficient experimental usage. The antibody is compatible with a wide range of experimental conditions and can be used in diverse research areas, such as cancer biology, signal transduction, and drug discovery.

With its exceptional performance and reliability, the ErbB-3(Phospho Tyr1289) Polyclonal Antibody is an indispensable tool for researchers aiming to investigate the role of ErbB-3 signaling pathway in various physiological and pathological processes.