ASK1(Phospho Thr838) Rabbit Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838| inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to| and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.|Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6| which in turn activate the JNK and p38 MAP kinases| respectively. Overexpression induces apoptotic cell death.|induction:By TNF-alpha. Inhibited by HIV-1 Nef.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|Contains 1 protein kinase domain.|subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.|tissue specificity:Abundantly expressed in heart and pancreas.|

The ASK1(Phospho Thr838) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of ASK1 protein phosphorylated at threonine 838 residue. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The ASK1(Phospho Thr838) Rabbit Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of ASK1 at threonine 838, making it an ideal choice for researchers studying the activation and regulation of ASK1 signaling pathway. With its superior sensitivity, this antibody enables the detection of even low levels of phosphorylated ASK1, facilitating accurate and precise quantification of protein expression levels.

This antibody is manufactured using advanced techniques and stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It has been extensively validated in various experimental conditions and has shown excellent performance in detecting phosphorylated ASK1 in a wide range of sample types, including cell lysates, tissue extracts, and whole-cell extracts.

The ASK1(Phospho Thr838) Rabbit Polyclonal Antibody offers researchers a reliable and robust tool for investigating the role of ASK1 phosphorylation in cellular processes and disease pathogenesis. Its high specificity, sensitivity, and versatility make it an indispensable asset for studies focused on understanding the molecular mechanisms underlying ASK1 signaling and its potential as a therapeutic target.

Order the ASK1(Phospho Thr838) Rabbit Polyclonal Antibody today and unlock new insights into the intricate world of ASK1 signaling.