AS160(Phospho-Ser588) Rabbit Polyclonal Antibody

This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein| and contains two phopshotyrosine-binding domains (PTB1 and PTB2)| a calmodulin-binding domain (CBD)| a Rab-GTPase domain| and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4)| important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane| suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin| this protein is phosphorylated| dissociates from GLUT4 vesicles| resulting in increased GLUT4 at the cell surface| and enhanced glucose transport. Ph

The AS160(Phospho-Ser588) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of AS160 protein phosphorylated at Ser588. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

AS160, also known as TBC1D4, is a key regulator of glucose uptake in skeletal muscle and adipocytes. Phosphorylation of AS160 at Ser588 plays a crucial role in insulin-stimulated glucose transport by promoting the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Therefore, the AS160(Phospho-Ser588) Rabbit Polyclonal Antibody is an essential tool for studying the molecular mechanisms underlying glucose metabolism and insulin signaling.

This antibody has been rigorously validated to ensure high specificity and sensitivity. It exhibits minimal cross-reactivity with non-phosphorylated AS160 and other related proteins, ensuring accurate and reliable results. The AS160(Phospho-Ser588) Rabbit Polyclonal Antibody also demonstrates excellent reproducibility, allowing for consistent and precise quantification of AS160 phosphorylation levels.

With its superior performance and versatility, the AS160(Phospho-Ser588) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying glucose metabolism, insulin signaling, and related fields. Its high specificity, sensitivity, and reliability make it an ideal choice for a wide range of applications, enabling groundbreaking discoveries and advancements in the field of molecular biology.