Cyclin D3(Phospho Thr283) Polyclonal Antibody

The protein encoded by this gene belongs to the highly conserved cyclin family| whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6| whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

The Cyclin D3(Phospho Thr283) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of Cyclin D3 protein phosphorylated at Thr283. This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Cyclin D3 is a crucial regulator of the cell cycle, playing a pivotal role in cell proliferation and differentiation. Phosphorylation of Cyclin D3 at Thr283 has been implicated in the modulation of its activity and stability, making it an important target for research in the field of cell biology and cancer.

The Cyclin D3(Phospho Thr283) Polyclonal Antibody has been developed using state-of-the-art techniques, ensuring high specificity and sensitivity. It exhibits minimal cross-reactivity with non-phosphorylated Cyclin D3 and other related proteins, guaranteeing accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use. It has been optimized for use in various experimental conditions, providing consistent and reproducible results. The Cyclin D3(Phospho Thr283) Polyclonal Antibody is available in different sizes to meet the specific needs of researchers.

With its exceptional performance and reliability, the Cyclin D3(Phospho Thr283) Polyclonal Antibody is an indispensable tool for scientists studying cell cycle regulation, cancer biology, and related fields. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications.